American Journal of Epidemiology Vol. 114, No. 1: 21-28
Copyright © 1981 by The Johns Hopkins University School of Hygiene and Public Health
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SERUM CHOLESTEROL AND MORTALITY
THE YUGOSLAVIA CARDIOVASCULAR DISEASE STUDY
1 Institute of Chronic Diseases and Gerontology Slobodana Penezica 35, 11000 Belgrade, Yugoslavia
2 National Heart, Lung, and Blood Institute, Honolulu Heart Program 347 N. Kuakini Street, Honolulu, HI 96817
4 National Heart, Lung, and Blood Institute, Division of Heart and Vascular Disease, Program Coordination and Planning Bethesda, MD 20205
Send reprint requests to Dr. Kozarevic at this address
The relationship of level of baseline serum cholesterol to the seven-year incidence of death from all causes and from specific causes was examined in a cohort of 11,121 Yugoslav males aged 35–62 years at the time of their initial examination (1964–1965). Serum cholesterol was negatively related to mortality, i.e., those with a lower choiesterol experienced a higher mortality than those with a higher cholesterol. The negative relationship was significant (as assessed by logistic regression) and remained significant after adjusting for obesity, systolic blood pressure, cigarette smoking, age, history of intestinal parasitism, and socioeconomic status (as measured by years of education). The negative association of serum cholesterol and subsequent mortality appeared to be due to the relationship of cholesterol to deaths due to cancer and to deaths due to respiratory disease (tuberculosis and cor pulmonale). The cancer death-serum cholesterol relationship was not statistically significant but the respiratory disease death-serum cholesterol relationship was. Serum cholesterol, as expected, was positively related to the incidence of coronary heart disease death.
cholesterol; coronary disease; mortality; neoplasms; respiratory tract diseases
3NHLBI Consultant Statistician, Supported by NHLBI Contract #263-80-C-0057
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