American Journal of Epidemiology Vol. 110, No. 1: 63-69
Copyright © 1979 by The Johns Hopkins University School of Hygiene and Public Health
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ANTIBODY AGAINST HEPATITIS A IN SEVEN EUROPEAN COUNTRIES
I. COMPARISON OF PREVALENCE DATA IN DIFFERENT AGE GROUPS
SNER1,
1 Max von Pettenkofer-Institut für Hygiene und Medizinische Mikrobiologie, University of Munich Munich, West Germany
2 Department of Epidemiology and Medical Statistics, Athens School of Hygiene Athens, Greece
3 Blutspendedienst SRK, Zentrallaboratium Bern, Switzerland
4 Department of Infectious Diseases, University of Gothenburg Gothenburg, Sweden
5 Blood Center, Sahlgren's Hospital Gothenburg, Sweden
6 Centre National de Transfusion Sanguine Paris, France
7 Zentrallabor der Städtischen Krankenanstalten Esslingen, West Germany
Reprint requests to Dr. G. Frösner, Max von Pettenkofer-Institut der Universität München, Pettenkoferstr. 9a, D-8000 MÜnchen 2, West Germany.
Using a solid phase radioimmunoassay, antibody to hepatitis A virus (anti-HAV) was determined In 3890 sera from populations In seven European countries. Prevalence of anti-HAV was lowest in Scandinavian countries and highest in Greece and France. Antibodies were found In 77 (13%) of 602 blood donors in Sweden, in 29 (17%) of 175 blood donors and women taking birth control pills In Norway, in 273 (39%) of 700 blood donors in Switzerland, In 262 (52%) of 505 blood donors In Holland, in 365 (55%) of 661 accident patients in West Germany, In 452 (75%) of 600 blood donors in France and In 530 (82%) of 647 persons In Greece. Prevalence of anti-HAV Increased with age In all populations tested, Indicating nearly total exposure to HAV in persons over 19 years of age in Greece and In persons over 39 years of age In West Germany, Holland and France. Antibody was found more frequently in rural than in urban populations In Greece and Switzerland. Calculation of the age-specific Incidence of HAV Infections suggests a remarkable decline In the exposure rate in the last few decades.
age factors; antibodies; hepatitis A; prevalence studies; serology
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